The Wyoming Medication Donation Program (WMDP) improves prescription access for low-income patients (up to 200 percent of the federal poverty level) who lack adequate prescription coverage by re-dispensing donated medications, reducing waste and providing a comprehensive statewide network for drug donation. The Drug Donation Program Act was passed in 2005 and allows donation of in-date, unused medications in sealed packaging (excluding controlled substance and refrigerated drugs). The WMDP provides a statewide system for collecting medication donations, accepting referrals, re-dispensing medications, and mailing prescriptions. Qualified sites, including public health offices, pharmacies, hospitals, and charitable health clinics, registered with the program to collect donations. Reusable totes were provided for donation collection and shipment through the Wyoming Department of Health public health courier service free of charge to the collection site. This removed the cost barrier for participation and medications poured in. Since 2008, over 77,000 pounds of donations were processed, and there are currently 28 sites, covering 91 percent of Wyoming’s counties. The WMDP provides training, support, and shipment coordination for the sites.